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For many, the sedative power of poppies was introduced by Dorothy in the Wizard of Oz, galloping through flowers before falling fast asleep...Those blooms now provide raw materials for opioid painkillers used by the millions worldwide. But like the Wicked Witch of the West, who cast that poppy spell on Dorothy, the coronavirus pandemic has put a sleeper hold on the production of poppies for pharmaceutical use...The global demand for opium-based products plummeted last year as COVID forced the cancellation of most elective surgeries, and now, that diminished need for surgical pain relief products has forced Sun Pharma of India to reduce its number of contracted poppy growers in Tasmania and to eliminate two of its field officers...READ MORE

McKinsey & Company, the consultant to blue-chip corporations and governments around the world, has agreed to pay nearly $600 million to settle investigations into its role in helping “turbocharge” opioid sales, a rare instance of it being held publicly accountable for its work with clients...The firm has reached a $573 million agreement with attorneys general in 47 states, the District of Columbia and five territories, according to a court filing in Massachusetts on Thursday. Separate deals were announced in Washington State, for $13 million, and in West Virginia, for $10 million...The settlements come after lawsuits unearthed a trove of documents showing how McKinsey worked to drive sales of Purdue Pharma’s OxyContin painkiller...READ MORE

The Trump administration sued Walmart Inc. Tuesday, accusing the retail giant of helping to fuel the nation’s opioid crisis by inadequately screening for questionable prescriptions despite repeated warnings from its own pharmacists...The Justice Department’s lawsuit claims that Walmart sought to boost profits, understaffed its pharmacies and pressured employees to fill prescriptions quickly. That made it difficult for pharmacists to reject invalid prescriptions, enabling widespread drug abuse nationwide, the suit alleges...Walmart, the country’s largest retailer by revenue, has been expecting this complaint and sued the federal government in October to fight the allegations pre-emptively...In its suit, Walmart accuses the Justice Department and Drug Enforcement Administration of attempting to scapegoat the company for what it says are the federal government’s own regulatory and enforcement shortcomings...READ MORE

...Purdue Pharma has signed a massive settlement to walk away from federal civil and criminal charges. But as the company wades throught court-supervised bankruptcy, will the government—or individuals hurt by Purdue's bad behavior—see anywhere close to that amount in damages?...Purdue has reached an $8 billion-plus deal with the U.S. Department of Justice to plead guilty and settle federal criminal and civil claims for its role in fueling the nation's opioid epidemic...Purdue has been assessed a $3.54 billion criminal penalty and will forfeit an additional $2 billion, the government said. The company has also agreed to pay $2.8 billion to settle the government's civil claims. In addition, the company's founding Sackler family will forfeit $225 million in civil damages...READ MORE

A legislative committee unanimously passed a bill that would create a state fund to house proceeds from opioid settlements, such as those against prominent pharmaceutical companies accused of helping fuel the opioid crisis...The bill would establish the “Nevada Fund for Healthy Communities,” which would hold the proceeds of state litigation against opioid manufacturers, distributors, sellers and marketers — including the $45 million Nevada is set to receive from the settlement of a lawsuit against consulting firm McKinsey & Company, which provided services for opioid manufacturers...READ MORE

In the United States, methamphetamine overdose deaths surged from 2011 to 2018, according to a report from the National Institute on Drug Abuse...Rapid increases were seen across all racial and ethnic groups, but American Indians and Alaska Natives were most affected. Deaths involving methamphetamines more than quadrupled among non-Hispanic American Indians and Alaska Natives from 4.5 to 20.9 per 100,000 people, with sharp increases for both men and women in those groups...Methamphetamine use is linked to a range of serious health risks, including overdose deaths. Unlike for opioids, there are currently no FDA-approved medications for treating methamphetamine use disorder or reversing overdoses. However, behavioral therapies such as contingency management therapy can be effective in reducing harms associated with use of the drug, and a recent clinical trial reported significant therapeutic benefits with the combination of naltrexone and bupropion in patients with methamphetamine use disorder...READ MORE

In a first in the nation, Oregon has rejected charging drug users with criminal offenses, with voters passing a ballot measure that decriminalizes possession of heroin, methamphetamine, LSD, oxycodone and other hard drugs...“Today’s victory is a landmark declaration that the time has come to stop criminalizing people for drug use,” said Kassandra Frederique, executive director of the Drug Policy Alliance, which was behind the measure. “Measure 110 is arguably the biggest blow to the war on drugs to date.”...The measure completely changes how Oregon’s justice system treats those who are found with personal-use amounts of the hard drugs...READ MORE

Nevada has struck a $45 million settlement deal with McKinsey & Company for the global consulting firm’s role in advising opioid makers how to sell more prescription painkillers amid a national overdose crisis...The western state reached the deal after sitting out a multi-state settlement with McKinsey announced in February. The hard bargaining has allowed Nevada to win a settlement that’s three and a half times larger than the average settlement with other states...READ MORE

More than a decade ago, Purdue Pharma pleaded guilty to marketing the powerful painkiller OxyContin in a way that illegally downplayed its addictiveness and abuse potential. This past October, the company again admitted criminal wrongdoing for misleading doctors, regulators and the public regarding the drug’s dangers...Last Thursday’s congressional opioid hearing was the first time in years that the family behind Purdue, the Sacklers, would have a chance to take responsibility for it all. But instead of accepting blame for that reckless promotion, two of the family members, who appeared voluntarily under penalty of subpoena, did little more than murmur words of regret for the harmful commercial tactics that made their company’s lead product the poster child for the opioid crisis...While both apologized, neither acknowledged personal (or familial) fault or error...READ MORE

Walmart has filed suit against the United States Department of Justice and the Drug Enforcement Administration, asking a US District Court judge to clarify the roles and responsibilities of pharmacists and pharmacies under the Controlled Substances Act...Although Walmart’s pharmacies have blocked “thousands” of questionable physicians from having their opioids scripts filled by its pharmacists, “certain DOJ officials have long seemed more focused on chasing headlines than fixing the crisis,” the retailer said. “They are now threatening a completely unjustified lawsuit against Walmart, claiming in hindsight pharmacists should have refused to fill otherwise valid opioid prescriptions that were written by the very doctors that the federal government still approves to write prescriptions.”...READ MORE