Category:

Researchers can now predict the odds of experimental drugs succeeding in clinical trials, thanks to a new data-driven approach developed by Weill Cornell Medicine scientists. The method detects toxic side effects that may disqualify drugs from human use, giving drug developers an early warning before initiating clinical trials, according to a new study...The approach upends conventional wisdom about the criteria on which to evaluate new drugs for their safety. Rather than exclusively examining molecular structure to determine viability, this new computational method combines a host of structural features and features related to how the drug binds to molecules in the body...We looked more broadly at drug molecule features that drug developers thought were unimportant in predicting drug safety in the past. Then we let the data speak for itself…The method, known as PrOCTOR, was inspired by an approach that baseball statisticians adopted to better predict which players would be successful offensively...a strategy known as "Moneyball."...Similarly, researchers developed a computational method that analyzes data from 48 different features of a drug — from molecular weight to details about its target — to determine whether it would be safe for clinical use...this approach could improve the drug discovery pipeline, save money and save lives — but only if more data on toxicity results become available. After all, only 50 percent of clinical trial results are fully reported...if we don't have data, we can't build these models...

Arizona-based health services operator Banner Health said...that it was the victim of a cyberattack potentially affecting about 3.7 million patients, physicians, health plan members and others across seven states...The organization, which operates a community hospital in Fallon and facilities in Fernley, did not confirm whether any Nevada patients’ information was compromised in the attack...Jennifer Ruble said she didn’t yet have data on the number of people affected in each of the seven states in which the health system operates...The nonprofit system is mailing letters to possibly affected individuals, has contacted law enforcement and has taken actions to block cyberattackers, according to a statement...

Josh Stein, CEO and co-founder of AdhereTech, discusses how technology can enhance the ability of specialty pharmacies to manage their patients' therapy regimen.

The imminent chain-wide arrival of digital receipts was first unveiled on Friday evening on ABC's Jimmy Kimmel Live, in a surprise appearance featuring CVS Pharmacy President Helena Foulkes. The show acknowledged the...feedback shared by millions of customers – including host Jimmy Kimmel himself, who has put CVS Pharmacy receipts and ExtraCare Rewards in the spotlight several times in the past...We are excited to roll out the much-anticipated launch of digital receipts. We heard loud and clear that while our customers love receiving coupons and special offers, many wanted a paperless option...This feature lets our customers continue to make personalized choices as to how they engage with us, and will let our members choose to say 'So long!' to the long paper receipts at check-out...

Paul LeVine, vice president of Analytic Services at TrialCard, discusses how specialty pharmacies can best utilize data to improve patient outcomes.

Drug abuse, including misuse of prescription drugs, remains at alarmingly high levels...Feeding this epidemic, the National Association of Boards of Pharmacy says, are rogue Internet drug outlets illegally dispensing prescription controlled substances...illicit online drug sellers "hiding behind sleek websites" are making it easier for people struggling with drug abuse to purchase controlled-substance medications. However, since these rogue websites often sell counterfeit and tainted substances, buyers can raise the risk of overdose and death...researchers used popular search engines (Google, Bing and Yahoo), shopping websites (eBay, Craigslist, Yahoo! Shopping, Overstock.com, Etsy, Oodle, eCRATER, Bonanza, Sell.com, Blujay and Alibaba) and social media sites (YouTube and Twitter) to gauge the availability of the opioids Demerol, Dilaudid, Duragesic, Exalgo, Kadian, Lorcet, Lortab, Percocet, Roxicet, Vicodin and Zohydro. Opioids were easiest to find and readily available by using search engines, the researchers discovered. Still, no matter which online avenue was used, researchers found that the final destination was a dedicated website selling opioids illegally.

The U.S. Food and Drug Administration said...along with international authorities, has formally sought to suspend 4,402 websites that illegally sell potentially dangerous, counterfeit or unapproved prescription drugs to U.S. consumers...The move is part of a global effort being led by the INTERPOL...to identify the makers and distributors of illegal prescription drugs...the FDA said it has also issued warning letters to operators of 53 websites that illegally sell unapproved and misbranded prescription drug products to U.S. consumers...Preliminary findings...showed U.S. consumers had purchased certain unapproved drug products from abroad to treat depression, narcolepsy, high cholesterol, glaucoma, and asthma, among other conditions...

The notorious virus is running rampant through global phishing campaigns to a wide range of industries, but U.S. healthcare is ground zero...Locky ransomware is back in the spotlight...the virus has evolved and is targeting hospitals with a massive campaign...The ransomware strain – first observed by security researchers in February this year – began as a straight-forward virus sent in an email attachment disguised at a Microsoft Word invoice...This latest campaign, however, uses DOCM files (macro-enable files used in Microsoft Word) to deliver the ransomware payload...Further, these are global attacks, but the U.S. tops the list…Each email campaign has distinct ‘one-off’ codes, used to download Locky from the malware server and the malicious URL is embedded within macro code, using the same encoding function...The volume of Locky ransomware downloaders is increasing and the tools and techniques being used in campaigns are constantly changing...

When health care behemoth Johnson & Johnson decided last year to use Veeva Systems' software for gathering data from clinical trials needed to get a new drug approved, Veeva's rivals took notice..."They (J&J) said we're going to standardize this globally, and within 12 months we had 6 customers (among the 20 biggest drugmakers) do the exact same thing,"...one... goal in mind -- replace biopharma companies' legacy systems with cloud-based software designed to make their painstaking regulatory requirements a lot less painful...The cost of developing a new drug has soared to $2.6 billion, up from about $1 billion in 2000 in inflation-adjusted dollars, according to the Pharmaceutical Research and Manufacturers of America. Because the stakes are so high, more large drug developers have decided in rapid succession to junk their prior technology investments...The key to Veeva's success is that it has brought together enterprise software expertise with industry-specific expertise...

Robert Sztar is the founder of Pharmactive and has developed a unique 4-step method of ‘Transpharmation’ which covers:

1. Education – I teach you the purpose of the currently available technologies.
2. Discovery – I help pharmacy owners to discover processes in their business which can be aided or automated by technology
3. Partnership – I introduce pharmacy owners to the right technology partners who will help them to plan, implement, train and maintain their products in their pharmacy.
4. Optimisation – I help you review the solutions implemented to ensure that the original objectives have been delivered upon, and discussing areas of potential improvement.  (podcast 24:29 min)