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Collaborating with academia has been de rigueur in the pharma world for years, but it's a different game these days. Recognizing that scientists on both sides of the divide can't be distant neighbors anymore, drugmakers and academics are invading each other's personal space, even working side-by-side in the same labs. They're learning unexpected things about their counterparts. And they're coming to terms with the inherent conflict between research for curiosity's sake and research for the market…optimistic about their collaborative efforts, regardless of the challenges...innovation isn't innovation unless it's put to use--i.e., taken to market--would be anathema to many academics…we try to find the best brains and give them the freedom to pursue their curiosity,"…"Basically many leading academics don't do well in structured programs."..."Our worlds are approaching each other more and more,"…and as the results of these collaborations begin to hit the market, that will give the very idea a boost…global trends will make collaborations an even more important part of working in the pharma business: "Now, with the internet, how information flows, how this generation moves across the globe, with the knowledge-driven economy, you'll see the boundaries between institutions blur even more."

Allergan and New York State have settled a heated antitrust lawsuit that accused the drug maker of switching patients from an older dementia pill to a newer and more expensive version in order to avoid generic competition…Allergan agreed to pay $172,000 in litigation expenses and withdraw an appeal filed last month with the US Supreme Court…The arrangement ends a bitterly fought battle over a pharmaceutical industry practice known as forced switching or product hopping. This involves pushing consumers from one product to another. The case was closely watched because it held the potential to decide the extent to which a drug maker can force a product switch without running afoul of antitrust laws…The lawsuit triggered a debate over the sometimes controversial practice of reformulating a medicine and then obtaining a patent to extend its product life cycle. But the move by Allergan highlighted competing arguments over whether the strategy is really a ruse to create an unfair monopoly or is a legitimate use of intellectual property to protect a profitable product.

Healthcare IT security: you have a bad reputation. When it gets down to healthcare there’s always a little chuckle about how bad they are…This year was among the worst in cybersecurity across the healthcare sector…On average, companies that got breached did not know it for 270 days and some had even been breached for seven years without knowing it…that two-thirds of those entities did not even discover the breach internally; it was pointed out to them, either by someone outside the organization or by the federal government...As bad as breaches are, however, there are other worse threats emerging that hospital CIOs, CISOs and IT departments should understand and prepare for.

1. Ransomware
2. DDoS (Distributed Denial of Services)
3. Wiper attacks
4. Intellectual property theft
5. Straight theft of money
6. Data manipulation
7. Data destruction

Doctors who entered data into computerized health records during patients' appointments did less positive communicating, and patients rated their care excellent less often…Many clinicians worry that electronic health records keep them from connecting with their patients…doctors who used the computer more also spent more time correcting or disagreeing with patients…Doctors who spent more time using the computer spent less time making eye contact with patients and tended to engage in more “negative rapport building,” correcting patients about their medical history or drugs they’ve taken based on information in the electronic record…That’s not necessarily a bad thing…Doctors who spend most of the time looking at the computer may miss out on an emotional connection with the patient…When people are paying attention to the same thing at the same time, you get the best transmission of information… Electronic health records need to be more usable so clinicians with varying computer proficiency can use them without struggling and diverting focus from patients…

Foreign pharmaceutical firms are looking for the bright side in Russia’s import substitution plan for the drug manufacturing sector…When…Prime Minister Dmitry Medvedev tasked the government with creating a program of import substitution in the field of pharmaceutical production, foreign companies were worried. Although Russia’s pharmaceutical market…a fraction of that of the U.S…its loss would have been a blow to Western drug companies at a time of global economic crisis...the policy may not have such serious implications…the import substitution policies will only affect sales to public health organizations, primarily state-run hospitals and pharmacies. Private health clinics and pharmacies are still able to import foreign drugs without restrictions…60 percent of the drugs on the List of Vital and Essential Medicines approved by Russian government bodies for use in public institutions are produced domestically. Under the new policy, this share should increase to 90 percent by 2018.

Express Scripts, the nation’s largest pharmacy benefits manager, will cover a new compounded version that costs just $1 a tablet. Moreover, two leading physicians’ groups quickly endorsed the move…The decision comes amid ongoing controversy over Daraprim, which Turing bought last summer from another company and then boosted the price from $13.55 a pill to $750, a 5,000 percent increase. The price hike triggered a new round of scrutiny of pharmaceutical costs and transformed Shkreli…into a poster boy for greed and outsized drug pricing…Turing took steps to thwart lower-cost generic competition by using a so-called closed distribution system. The drug maker is unwilling to sell Daraprim to other companies and, without sufficient supplies, a generic drug maker is unlikely to have enough medicine to run clinical tests needed for FDA approval…This explains why the compounded version is being embraced.

Before…Theranos suspended use of its finger-prick blood draws in September because of Food and Drug Administration concerns, the company tangled with Arizona lab regulators over testing instruments and lab practices…Theranos, which operates retail locations inside 40 Walgreens stores across metro Phoenix, did not always meet lab regulations before taking corrective steps, according to inspection reports…After an April 2 survey of the company's Scottsdale lab, Arizona Department of Health Services inspectors noted four "deficiencies" at the lab...The state inspectors conducted the survey on behalf of the federal Centers for Medicare and Medicaid Services, which regulates laboratory testing…The four issues concerned proficiency testing, validation of instruments used to analyze blood samples, humidity levels outside of acceptable ranges for some lab instruments and how blood-sample collections were dated…In September, state lab inspectors said that Theranos did not meet proficiency testing standards for certain substances, including toxicology and four other regulated substances.

Last week, Jim Cramer learned that the much-discussed merger between Allergan and Pfizer is really happening. This would create the world's largest pharmaceutical deal, with $160 billion in an all stock transaction…The deal stipulated that Allergan shareholders would receive 11.3 shares of Pfizer for every one share of Allergan…"Even though I think this is a very smart deal, one that will give Pfizer a tremendous pipeline of new drugs along with a lower Irish corporate tax rate, the market initially seemed pretty skeptical,"…Allergan's stock initially sold off on the news, as investors worried what could be in it for them on the deal. However, since that time the stock has rebounded…many questions remain on how the transaction will reward Allergan shareholders, given how much the company already has going for it on its own. That is why Cramer decided to go straight to the source, and spoke with Allergan's CEO Brent Saunders.

The congressman didn’t mince words when the Food and Drug Administration aired a plan to regulate diagnostic tests at a recent hearing. That could slow approvals, Representative Christopher Collins warned: “You run the risk of causing people to die.”…What Collins didn’t say at the hearing was that he has a financial stake in the issue: He co-founded a company that makes components for those tests. And he retains an ownership stake in that company, an asset he values at between $5 million and $25 million…Welcome to Congress, where such arrangements are legal — and to many critics, deeply disturbing…analysis of thousands of pages of congressional disclosure forms found that about 30 percent of senators and 20 percent of representatives held assets in biomedical and health-care companies, or in specialty funds set up to invest in those industries, during 2014…Some of the most aggressive congressional investors in the biomedical sector also sit on key committees, such as the House Judiciary Committee, which has jurisdiction over patent law, or the House Energy and Commerce Committee, which oversees the Food and Drug Administration and works on many issues of critical importance to the industry, including drug regulation, research funding, and taxes on medical devices…Members of Congress are not required to recuse themselves from voting on bills that could affect their personal finances, unless they would be the primary beneficiary of the legislation.

UnitedHealth Group Inc. should have stayed out of Obamacare’s new individual markets longer, the chief executive officer of the biggest U.S. health insurer said…after announcing last month that it will take hundreds of millions of dollars in losses related to the business…While the company’s other lines of business are growing, instead of expanding into Obamacare next year, the company should have kept waiting, UnitedHealth CEO Stephen Hemsley said…“It was for us a bad decision,”…“I take accountability for sitting out the exchange market in year one so we could in theory observe, learn and see how the market experience would develop. This was a prudent going-in position. In retrospect, we should have stayed out longer.”…UnitedHealth is not alone in its Obamacare struggles. Other insurers, including competitors Anthem Inc. and Aetna Inc., have also either suffered losses in the markets or said they haven’t seen the margins they expected.