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Replacing daily pills with a weekly regimen could help patients stick to their dosing schedule... Researchers at Massachusetts Institute of Technology and Brigham and Women’s Hospital have developed a capsule that can deliver a week’s worth of human immunodeficiency virus drugs in a single dose. This advance could make it much easier for patients to adhere to the strict schedule of dosing required for the drug cocktails used to fight the virus...The new capsule is designed so that patients can take it just once a week, and the drug will release gradually throughout the week. This type of delivery system could not only improve patients’ adherence to their treatment schedule but also be used by people at risk of HIV exposure to help prevent them from becoming infected...The MIT/BWH team is also working on adapting this technology to other diseases that could benefit from weekly drug dosing. Because of the way that the researchers designed the polymer arms of the capsule, it is fairly easy to swap different drugs in and out, they say. They are also working on capsules that could stay in the body for much longer periods of time...

The digital start-up Capsule, which opens for business...in New York City, is looking to compete in the already crowded Big Apple pharmacy market by focusing on home delivery of prescription drugs...At the same time, Capsule is eschewing selling customers candy, soda, shampoo, greeting cards and other nonpharmaceutical items...Capsule aims to solve what its executives call the "existing pain points" of conventional, bricks-and-mortar pharmacies: long wait times to get prescriptions filled; having to return to the store because a drug is out of stock; uncertainty about how much a drug will cost a patient; and getting questions answered about drugs...Instead of walking into a store, most of the start-up's customers will get their medications hand-delivered by couriers dispatched throughout the city — with the temporary exception of Staten Island — via bicycle, buses and subways, and by foot, after their doctors file the prescription electronically...To build its business, Capsule will rely on consumer and doctor awareness. Patients can request the service, or doctors can recommend it...We think eliminating folks going into the store is one way of creating a better experience or energy...Capsule is launching its new way of running a pharmacy in New York City...This would certainly make sense in a number of other markets across the country, if not most everywhere...

Pfizer is targeting a deadly bacterium that thrives in hospitals…Staphylococcus aureus can strike healthy, young people with no known risk factors, survive a barrage of antibiotics, and sometimes be fatal…One antibiotic-resistant strain frequently found in hospitals (MRSA) is responsible for about 75,000 serious infections and 10,000 deaths…a year…The pharmaceutical giant has spent more than 15 years working on a vaccine…and is in the midst of testing it on patients…Staph is a very difficult organism to make a vaccine against...Pfizer’s researchers are trying a multipronged approach. Two of the vaccine’s components go after a capsule that cloaks the bacterium and prevents the immune system from recognizing it. Another deprives the organism of manganese…A fourth targets the mechanism staph uses to lodge itself in the body…