- Another antibiotic crisis: fragile supply leads to shortages (reuters.com)
Shortages of some life-saving antibiotics are putting growing numbers of patients at risk and fuelling the evolution of “superbugs” that do not respond to modern medicines...The non-profit Access to Medicine Foundation said there was an emerging crisis in the global anti-infectives market as fragile drug supply chains - reliant on just a few big suppliers - come close to collapse...Global demand for antibiotics has grown by two-thirds since 2000, driven by population growth and the need for medicines to fight infectious diseases in low- and middle-income countries...Most antibiotics are cheap, off-patent generic medicines, which is good for affordability. But that also means they have very low profit margins - particularly compared to modern drugs for diseases like cancer - offering manufacturers little incentive to invest in new production facilities...antibiotic shortages can have especially dire consequences, since doctors have to resort to sub-optimal treatments that are less efficient at killing specific pathogens, leading to the rise of resistant bacteria or so-called superbugs...
- At least 20,000 infected in southeast Congo measles outbreak: U.N. (reuters.com)
..measles outbreak in the copper-mining Katanga province in the Democratic Republic of Congo has killed 315 people and infected at least 20,000,…Hundreds more deaths have likely not been documented due to difficulties accessing remote areas,…province's worst outbreak of the disease since 2010….
- Lab-Grown Mini Organs Could Speed Up Drug Discovery (forbes.com)
The thought of lab-grown organs conjures up Frankenstein-like imagery. The reality however, is somewhat less visually dramatic, with the term ‘organoids’ used to describe tiny 3D structures of human tissue, a millimeter or so in diameter...these tiny lumps of cells are creating a lot of excitement in the world of medical research...Cells in dishes and animal models have been used for preclinical testing of drugs for decades. Success in these experiments is a key hurdle for any new medicine to overcome before being given the green light for all-important human clinical trials...Organoids are most commonly made either from a small sample of tissue needled out of a person or from stem cells cultured in a cocktail of nutrients intent on pushing them towards becoming a particular tissue type. So far, organoids have been made resembling several tissues including lung, liver, brain, kidney and intestine...as a relatively new innovation they are being used to investigate dozens of conditions from infectious diseases to cancer.... A study published last year in Science Translational Medicine by scientists at the University Medical Centre, Utrecht generated organoids formed from the rectal tissue of 71 people with cystic fibrosis and exposed them to experimental drugs. By observing changes in the organoids, the scientists accurately predicted which patients would respond to the therapies in just one week at a cost of around $1200 per patient. The results were so convincing that a positive organoid test is now considered sufficient evidence for insurance companies to fund the new therapies in the Netherlands...
- Armada partners with UMass med school to enhance specialty platform (drugstorenews.com)
Armada Health Care…announced a partnership with the clinical pharmacy services unit at the University of Massachusetts Medical School to help improve and provide support for the specialty pharmacy group contractor’s ArmadaOne specialty pharmacy workflow platform…The collaboration will. …support… therapy interventions and clinical protocols..
- Germany, U.S. in hot pursuit of ‘messenger’ drug molecules (newsdaily.com)
A molecule that carries the recipe for making drugs inside body cells is exciting scientists and investors alike, attracting hundreds of millions of dollars in a scramble for the next promising area of biotechnology… synthetic messenger RNA, or mRNA technology, a new approach to tackling a range of hard-to-treat diseases... In theory, the promise of mRNA is enormous, ranging from cancer to infectious diseases to heart and kidney disorders, since it could be used to tackle the 80 percent of proteins that are difficult to affect with existing medicines…In effect, mRNA serves as software that can be injected into the body to instruct ribosomes, the “3D-printers” found inside cells, to churn out desired proteins…This is a radically different approach from conventional approaches, where therapeutic proteins are produced outside the human body and…then be inserted back into the human body at great complexity and cost…“The field is moving very rapidly,”...“I predict it will have a significant impact.”...
- Gadget Guide: 5 Helpful Apps for Pharmacy Students (pharmacytimes.com)
- FDA Drug Shortages current drug shortages, resolved shortages, and discontinuations of drug products (free)
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- iPHARMACY - Drug Guide & Pill Identifier (free)